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Peer-reviewed publications： (# equal contribution, please be aware of the copy right policies and these articles should not be disseminated without permission from the publishers. ) 

 

2019

    1.  Yahui Ji, Dongyuan Qi, Linmei Li, Haoran Su, Xiaojie Li, Yong Luo, Bo Sun, Fuyin Zhang, Bingcheng Lin, Tingjiao                    Liu*,  Yao Lu* Multiplexed Profiling of Single-cell Extracellular Vesicles Secretion. PNAS, 2019, 116 (13) 5979-5984.

          Notable coverage:

            Chinese Academy of Sciences: Scientists Realize Multiplexed Profiling of Single-cell Extracellular Vesicle Secretion

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    2.  Zhuo Chen#, Yao Lu#*, Kerou Zhang, Yang Xiao, Jun Lu, Rong Fan* Multiplexed, sequential secretion analysis of the               same single cells reveals distinct effector response dynamics dependent on the initial basal state.

         Advanced Science, 2019,  6, 1801361. (Highlighted as Inside Cover)

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    3.  Nayi Wang, Yao Lu, Zhuo Chen, Rong Fan* Multiplexed PCR-free detection of microRNAs in single cancer cells.                       Micromachines, 2019, 10(4), 215.

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    4.  Jiu Deng, Xiuli Zhang, Zongzheng Chen, Yong Luo*, Yao Lu, Tingjiao Liu, Zhengzhi Wu, Yu Jin, Weijie Zhao,                           Bingcheng Lin A cell lines derived microfluidic liver model for investigation of hepatotoxicity induced by drug-drug                   interaction. Biomicrofluidics, 2019, 13, 024101. 

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    5.  Jun Ma#, Shiqiang Yan#, Chunyue Miao, Linmei Li, Weiwei Shi, Xianming Liu,  Yong Luo, Tingjiao Liu,

         Bingcheng Lin, Wenming Wu,*, Yao Lu*

         Paper Microfluidics for Cell Analysis.  Advanced Healthcare Materials, 2019, 8, 801084.

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2018

    1. Yong Luo*, Xiuli Zhang, Yujiao Li, Jiu Deng, Xiaorui Li, Yueyang Qu, Yao Lu, Tingjiao Liu, Zhigang Gao and                            Bingcheng Lin  High-glucose 3D INS-1 cell model combined with a microfluidic circular concentration gradient                          generator for high throughput screening of drugs against type 2 diabetes. RSC Adv., 2018, 8, 25409-25416.

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    2.  Li X, He J, Shao M, Cui B, Peng F, Li J, Ran Y, Jin D, Kong J, Chang J, Duan L, Yang X, Luo Y, Lu Y, Lin B, Liu                       T*. Downregulation of miR-218-5p promotes invasion of oral squamous cell carcinoma cells via activation of CD44-                  ROCK signaling. Biomedicine & Pharmacotherapy, 2018, 106, 646-654.

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    3. Ruihan Bai, Linmei Li, Meimei Liu, Shiqiang Yan, Chunyue Miao, Ruijun Li, Yong Luo, Tingjiao Liu, Bingcheng                      Lin, Yibing Ji*, and Yao Lu* Paper Based 3D Scaffold for Multiplexed Single Cell Secretomic Analysis.

        Analytical   Chemistry, 2018, 90, 5825−5832. (Featured in the Analytical Chemistry website)

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     4. Linmei Li, Shiqiang Yan, Bingcheng Lin, Qihui Shi*, Yao Lu* 

        Single-Cell Proteomics for Cancer  Immunotherapy Advances in Cancer Research, 2018, Volume 139, 185-207.

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     5. Yueyang Qu, Fan An, Yong Luo*, Yao Lu, Tingjiao Liu, Weijie Zhao, Bingcheng Lin. A nephron model for study of                    drug-induced acute kidney injury and assessment of drug-induced nephrotoxicity. Biomaterials, 2018, 155, 41-53.

 

2017

    1.Yao Lu, Liu Yang, Wei Wei*, Qihui Shi* Microchip-Based Single-Cell Functional Proteomics for Biomedical Applications         . Lab on a Chip, 2017, 17(7):1250-1263. (Lab on a Chip 2017 Most Downloaded Articles)

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    2. Shimeng Fang, Hongzhu Tian, Xiancheng Li, Dong Jin, Xiaojie Li, Jing Kong, Chun Yang, Xuesong Yang, Yao Lu, Yong            Luo, Bingcheng Lin, Weidong Niu*, Tingjiao Liu* Clinical application of a microfluidic chip for immunocapture and         quantification of circulating exosomes to assist breast cancer diagnosis and molecular classification. PLoS One. 2017 Apr          3;12(4):e0175050. doi: 10.1371/journal.pone.0175050. eCollection 2017.

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    3. 高志刚, 郑婷婷, 邓九, 李晓瑞, 曲玥阳, 陆瑶, 刘婷娇, 罗勇*, 赵伟杰, 林炳承 基于便携拉曼光谱仪和双层纸芯片的头          发皮质醇超高灵敏检测 化学学报(Acta Chim. Sinica), 2017, 75, 355-359

 

2016

  1. Kun Zou, Zhigang Gao, Quanfeng Deng, Yong Luo, Lijuan Zou, Yao Lu, Weijie Zhao and Bingcheng Lin Picomolar detection of carcinoembryonic antigen in whole blood using microfluidics and surface-enhanced Raman spectroscopy. Electrophoresis, 2016, 37(5-6):786-9.  

  2. Jing Kong, Yong Luo, Dong Jin, Fan An, Wenyuan Zhang, Lilu Liu, Jiao Li, Shimeng Fang, Xiaojie Li, Ting Liu, Yizuo Wang, Yinzhu Zhao, Xuesong Yang, Bingcheng Lin*, Tingjiao Liu*. A multiple-organ-chip can mimic the organ-specific metastasis of circulating tumor cells in animals. Oncotarget, 2016, DOI:10.18632/oncotarget.9382

  3. Fan An，Yueyang Qu，Yong Luo*，Ning Fang，Yang Liu，Zhigang Gao，Weijie Zhao，Bingcheng Lin*，A Laminated Microfluidic Device for Comprehensive Preclinical Testing in the Drug ADME Process，Scientific Reports，2016，6：25022.

  4. Jin D, Ma X, Luo Y, Fang S, Xie Z, Li X, Qi D, Zhang F, Kong J, Li J, Lin B*, Liu T*. Application of a microfluidic-based perivascular tumor model for testing drug sensitivity in head and neck cancers and toxicity in endothelium. RSC Advances, 2016, 6 (35), 29598 – 29607

  5. M. Zhou†, X.Zhang†, X.Wen, T. Wu，W.Wang, M.Yang, J. Wang, M. Fang, B. Lin*, H. Lin*. Development of a functional glomerulus at the organ level on a chip to mimic renal diseases. Scientific Reports, 2016;6: 25022

  6. Zheng, T., Z. Gao, Y. Luo*, X. Liu*, W. Zhao and B. Lin (2016). "Manual-slide-engaged paper chip for parallel SERS-immunoassay measurement of clenbuterol from swine hair." Electrophoresis, 37(3): 418-424.

  7. Wang, D*., W. Zha, L. Feng, Q. Ma, X. Liu*, N. Yang, Z. Xu, X. Zhao, J. Liang, T. Ren and X. Wang (2016). "Electrohydrodynamic jet printing and a preliminary electrochemistry test of graphene micro-scale electrodes." Journal of Micromechanics and Microengineering 26(4).

  8. 林炳承 微流控芯片的研究及产业化，分析化学，2016,4(44):491-499

 

Before 2016 

  1. Qiong Xue#, Yao Lu#, Markus R. Eisele, Endah S. Sulistijo, Nafeesa Khan, Rong Fan*, and Kathryn Miller-Jensen* Analysis of single cell secretion reveals a role for paracrine signaling in coordinating macrophage response to TLR4 stimulation. Science Signaling, 2015, 8(381), ra59.

  2. Yao Lu#, Qiong Xue#, Markus Eisele, Endah Sulistijo, Kara Brower, Lin Han, El-ad David Amir, Dana Pe’er, Kathryn Miller-Jensen* & Rong Fan* Highly multiplexed profiling of single-cell effector functions reveals deep functional heterogeneity in response to pathogenic ligands. PNAS, 2015, 112 (7), E607-E615.

  3. Yao Lu#, Jonathan J. Chen#, Luye Mu, Qiong Xue, Yu Wu, Pei-Hsun Wu, Jie Li, Alexander O. Vortmeyer, Kathryn Miller-Jensen, Denis Wirtz, and Rong Fan* High-Throughput Secretomic Analysis of Single Cells to Assess Functional Cellular Heterogeneity. Analytical Chemistry 2013, 85 (4), 2548–2556

  4. Yao Lu, Bingcheng Lin*, Jianhua Qin*. Patterned Paper as a Low-cost, Flexible Substrate for Rapid Prototyping PDMS Microdevices via “liquid molding” . Analytical Chemistry 2011, 83 (5), 1830–1835

  5. Yao Lu, Weiwei Shi, Jianhua Qin*, Bingcheng Lin*. Fabrication And Characterization of Paper Based Microfluidics Prepared in Nitrocellulose Membrane By Wax Printing. Analytical Chemistry 2010, 82, 329–335 

  6. Yao Lu, Weiwei Shi, Lei Jiang, Jianhua Qin*, Bingcheng Lin*. Rapid prototyping of paper-based microfluidics with wax for low-cost, portable bioassay . Electrophoresis 2009, 30, 1497–1500

  7. Yao Lu, Weiwei Shi, Jianhua Qin*, Bingcheng Lin*. Low cost, portable detection of gold nanoparticle-labeled microfluidic immunoassay with camera cell phone. Electrophoresis 2009, 30, 579–582 (selected by editor as Fast Track)

  8. Lei Jiang, Yao Lu, Zhongpeng Dai, Minhao Xie, Bingcheng Lin*.  Mini-electrochemical Detector for Microchip Electrophoresis. Lab Chip 2005, 5(9), 930-934

  9. Lei Jiang, Xuening Jiang, Yao Lu, Zhongpeng Dai, Minhao Xie, Jianhua Qin*, Bingcheng Lin*. Development of a universal serial bus-powered mini-high-voltage power supply for microchip electrophoresis. Electrophoresis 2007, 28(8), 1259–1264.

  10. Weiwei Shi, Hui Wen, Yao Lu, Yang Shi, Bingcheng Lin*，Jianhua Qin* Droplet Microfluidics for Characterizing the Neurotoxin-induced Responses in Individual Caenorhabditis elegans. Lab Chip, 2010, 10, 2855 – 2863

  11. Wu Y, Lu Y, Chen WQ, Fu JP & Fan R*. In silico experimentation of glioma microenvironment development and anti-tumor therapy. PLoS Computational Biology, 8(2), 1002355 (2012).

  12. Lee SK*, Kim GS, Wu Y, Kim DJ, Lu Y, Kwak M, Han L, Hyung JH, Seol JK, Sander C, Gonzalez A, Li J, Fan R*. Nanowire Substrate-Based Laser Scanning Cytometry for Quantitation of Circulating Tumor Cells. Nano Letters, 12(6), 2697-2704(2012)

  13. Minsuk Kwak, Luye Mu, Yao Lu, Jonathan Chen, Yu Wu, Kara Brower and Rong Fan*. Single-cell protein secretomic signatures as potential correlates to tumor cell lineage evolution and cell-cell interaction. Frontiers in Oncology, 2013; 3: 10

  14. Meltem Elitas†, Kara Brower†, Yao Lu, Jonathan J. Chen and Rong Fan* A Microchip Platform for Interrogating Tumor-Immune Cell Communication at the Single-Cell Level. Lab on a Chip 14 (18), 3582-3588

  15. Mao, Lin†; Shen, Li†; Chen, Jiahui; Wu, Yu; Kwak, Minsuk; Lu, Yao; Xue, Qiong; Pei, Jia; Zhang, Lei; Yuan, Guangyin; Fan, Rong; Ge, Junbo; Ding, Wen-Jiang Enhanced bioactivity of Mg-Nd-Zn-Zr alloy achieved with nanoscale MgF2 surface for vascular stent application ACS applied materials & interfaces, 7 (9), 5320–5330.

 

Patents：

 

 1．一种图案化生化分析试纸、其制作方法及应用 (2012年10月10日授权)

   秦建华; 陆瑶; 姜雷; 林炳承; CN200810011218  

  (该技术目前已被美国Diagnostic For All公司采用生产便携化诊断芯片)

 2．集成微泵阀的微流控芯片负压力夹流进样方法及专用芯片 (2012年5月23日授权)

   林炳承; 李博伟; 姜 雷; 陆 瑶; 戴忠鹏; 秦建华；CN200810011085.8

 3．System, Device and Method for High-throughput Multi-plexed Detection (2015年11月17日授权)

   Rong Fan, Yao Lu, Jonathan J Chen. US9188586B2

   (该专利已授权美国IsoPlexis 公司用于商业化开发，详细信息参考http://isoplexis.com)

 

 

 

 

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